Tanzil - Quran Navigator
The Ultimate Light and Path-finder to the Man kind..!!!
Sunday, March 10, 2013
Tuesday, June 7, 2011
Oxytocin and Borderline Personality Disorder
http://blogs.nature.com/
Often referred to as the "love drug" or "love hormone", oxytocin has attracted increasing interest from researchers in recent years. It was originally shown to modulate aspects of social attachment and pair bonding in animals such as the female prairie vole, whose monogamous nature is dependent on oxytocin. Recent research in humans has shown that oxytocin increases trust behavior in economic exchanges and increases perception of trustworthiness in human faces, as well as promoting emotion recognition and altruism. This evidence inspired hopes among some, particularly in the mainstream media, that science might have found a possible pharmacological target for humans who show deficits in prosocial behavior.
But recent evidence has complicated the narrative a bit.
Research has shown that oxytocin plays a role in increased emotional reactivity to both positive and negative social cues. For example, one study from 2009 (Shamay-Tsoory et al) had participants engage in a game of chance with another player (the actor). In one condition, the actor was made to win more than the participant, evoking feelings of envy in the participant. In another condition, the actor was made to lose more than the participant, evoking feelings of "schaudenfrude" or gloating. Participants who were administered oxytocin before playing showed increases in both envy and schaudenfrude (if oxytocin was involved only in enhancing prosocial behavior, we would expect to see the opposite result.) Other research has shown oxytocin increased approach behavior or affiliative drive rather than regulating positive or negative responding per se. And one recent study showed that oxycotin led humans to self-sacrifice for their own group while showing increased aggression toward out-group members. The gist of this set of findings is that oxytocin doesn't seem to bias individuals toward the positive, but rather can magnify whatever "stimuli" happens to be in someone's attentional spotlight, be it bad or good, thereby generating an increase in corresponding positive or negative emotional responses.
Jennifer Bartz and colleagues (2010) were curious to explore whether oxytocin could "correct" deficits in pro-social behavior in individuals with borderline personality disorder (BPD), a population famous for emotional instability, extreme impulsive behavior and identity confusion. People with BPD tend to be involved in intense, emotionally volatile relationships characterized by frequent arguing, repeated breakups and extreme aggression. This behavior often extends beyond their romantic relationships, as BPD individuals have also been shown to have difficulty cooperating with strangers. The existing body of research, Bartz et al suggested, offers up contrary predictions. On the one hand, oxytocin could be helpful in reducing the negative behaviors normally associated with BPD in favor of kinder, gentler behavior towards others. Alternatively, oxytocin might have increasingly negative effects for people with BPD, who are chronically concerned with (lack of) trust and abandonment and have difficulty cooperating with others. They're essentially fixed in a constitutively negative state when it comes to social interactions and increased oxytocin could decrease prosocial behavior even further. Additionally (or alternatively), the oxytocin system might be dysregulated in BPD and could produce different responses (vs. control) to oxytocin as a result.
Bartz and company designed an experiment in which the participant was paired with a partner (in reality, a virtual "computer" partner) to engage in an economic game. In this game, the participant was to make one of two choices that involved financial rewards. The catch was that the amount of the reward was also dependent upon the choice that their "partner" made.
Both players clearly make the most money if they both choose strategy A. But because the player has to make the choice before the partner, the decision involves an element of trust (if your partner defects, you get nothing. If your partner trusts you and you defect, you get $4 and she gets nothing.)
So, what did they find?
Results showed the following:
1. BPD people trusted their partners in an economic game less after they received oxycotin than when they received a placebo. 2. Additionally, when asked if they would be more likely to make a hypothetical decision that would punish their partner, even when they knew their partner had extended trust toward them, they were more likely to punish after Oxytocin than placebo.
Administration of oxytocin to BPD individuals actually decreased pro-social behavior (and increased antisocial behavior). As the experimenters suggest, increasing the salience of a social cue that makes trust issues salient may have caused BPD participants to rely on their normal strategy for trust-dependent social interactions; that is, defect and punish the partner. Or it might have motivated approach/affiliative behaviors which triggered memory of past experiences gone awry and set off chronic and ever-present concerns about trust and rejection (e.g. "reject and punish them before they can do the same to me."). Finally, the experimenters suggest the possibility that the oxytocin system itself may be dysregulated.
In short, the evidence doesn't offer overwhelming support for the notion that exogenously-administered oxytocin will be a useful clinical treatment for people with pro-social deficits, such as those with BPD. Additionally, it's difficult to imagine long-term benefits of oxytocin given that it's half life when administered intranasally is only about three minutes. It's been said that the most of the real action with regards to oxytocin is on the receptor end.
Often referred to as the "love drug" or "love hormone", oxytocin has attracted increasing interest from researchers in recent years. It was originally shown to modulate aspects of social attachment and pair bonding in animals such as the female prairie vole, whose monogamous nature is dependent on oxytocin. Recent research in humans has shown that oxytocin increases trust behavior in economic exchanges and increases perception of trustworthiness in human faces, as well as promoting emotion recognition and altruism. This evidence inspired hopes among some, particularly in the mainstream media, that science might have found a possible pharmacological target for humans who show deficits in prosocial behavior.
But recent evidence has complicated the narrative a bit.
Research has shown that oxytocin plays a role in increased emotional reactivity to both positive and negative social cues. For example, one study from 2009 (Shamay-Tsoory et al) had participants engage in a game of chance with another player (the actor). In one condition, the actor was made to win more than the participant, evoking feelings of envy in the participant. In another condition, the actor was made to lose more than the participant, evoking feelings of "schaudenfrude" or gloating. Participants who were administered oxytocin before playing showed increases in both envy and schaudenfrude (if oxytocin was involved only in enhancing prosocial behavior, we would expect to see the opposite result.) Other research has shown oxytocin increased approach behavior or affiliative drive rather than regulating positive or negative responding per se. And one recent study showed that oxycotin led humans to self-sacrifice for their own group while showing increased aggression toward out-group members. The gist of this set of findings is that oxytocin doesn't seem to bias individuals toward the positive, but rather can magnify whatever "stimuli" happens to be in someone's attentional spotlight, be it bad or good, thereby generating an increase in corresponding positive or negative emotional responses.
Jennifer Bartz and colleagues (2010) were curious to explore whether oxytocin could "correct" deficits in pro-social behavior in individuals with borderline personality disorder (BPD), a population famous for emotional instability, extreme impulsive behavior and identity confusion. People with BPD tend to be involved in intense, emotionally volatile relationships characterized by frequent arguing, repeated breakups and extreme aggression. This behavior often extends beyond their romantic relationships, as BPD individuals have also been shown to have difficulty cooperating with strangers. The existing body of research, Bartz et al suggested, offers up contrary predictions. On the one hand, oxytocin could be helpful in reducing the negative behaviors normally associated with BPD in favor of kinder, gentler behavior towards others. Alternatively, oxytocin might have increasingly negative effects for people with BPD, who are chronically concerned with (lack of) trust and abandonment and have difficulty cooperating with others. They're essentially fixed in a constitutively negative state when it comes to social interactions and increased oxytocin could decrease prosocial behavior even further. Additionally (or alternatively), the oxytocin system might be dysregulated in BPD and could produce different responses (vs. control) to oxytocin as a result.
Bartz and company designed an experiment in which the participant was paired with a partner (in reality, a virtual "computer" partner) to engage in an economic game. In this game, the participant was to make one of two choices that involved financial rewards. The catch was that the amount of the reward was also dependent upon the choice that their "partner" made.
Both players clearly make the most money if they both choose strategy A. But because the player has to make the choice before the partner, the decision involves an element of trust (if your partner defects, you get nothing. If your partner trusts you and you defect, you get $4 and she gets nothing.)
So, what did they find?
Results showed the following:
1. BPD people trusted their partners in an economic game less after they received oxycotin than when they received a placebo. 2. Additionally, when asked if they would be more likely to make a hypothetical decision that would punish their partner, even when they knew their partner had extended trust toward them, they were more likely to punish after Oxytocin than placebo.
Administration of oxytocin to BPD individuals actually decreased pro-social behavior (and increased antisocial behavior). As the experimenters suggest, increasing the salience of a social cue that makes trust issues salient may have caused BPD participants to rely on their normal strategy for trust-dependent social interactions; that is, defect and punish the partner. Or it might have motivated approach/affiliative behaviors which triggered memory of past experiences gone awry and set off chronic and ever-present concerns about trust and rejection (e.g. "reject and punish them before they can do the same to me."). Finally, the experimenters suggest the possibility that the oxytocin system itself may be dysregulated.
In short, the evidence doesn't offer overwhelming support for the notion that exogenously-administered oxytocin will be a useful clinical treatment for people with pro-social deficits, such as those with BPD. Additionally, it's difficult to imagine long-term benefits of oxytocin given that it's half life when administered intranasally is only about three minutes. It's been said that the most of the real action with regards to oxytocin is on the receptor end.
Tuesday, September 28, 2010
Proton size is smaller than what we have now with..!!
ഒറ്റമൈന: Proton size is smaller than what we have now with-...: "The proton seems to be 0.00000000000003 millimetres smaller than researchers previously thought, according to work published in today's issu..."
Tuesday, October 7, 2008
Tuesday, September 16, 2008
"A WORHFUL HADITH"...read & have the essence of it...
Rasulullah (Sallallahu alaihe wasallam) said:
'When a man dies and his relatives are busy in funeral, there stands an extremely handsome man by his head. When the dead body is shrouded, that man gets in between the shroud and the chest of the deceased.
When after the burial, the people return home, 2 angels, Munkar and Nakeer(names of two special Angels), come in the grave and try to separate this handsome man so that they may be able to interrogate the dead man in privacy about his faith. But the handsome man says, 'He is my companion, he is my friend. I will not leave him alone in any case. If you are appointed for interrogation, do your job. I cannot leave him until I get him admitted into Paradise '.
Thereafter he turns to his dead companion and says, 'I am the Qur'an, which you used to read, sometimes in a loud voice and sometimes in a low voice. Do not worry. After the interrogation of Munkar and Naker, you will have no grief.'
When the interrogation is over, the handsome man arranges for him from Al-Mala'ul A'laa (the angels in Heaven) silk bedding filled with musk.
Rasulullah (Sallallahu alaihe wasallam) said:
'On the Day of Judgement, before Allah, no other Intercessor will have a greater status than the Qur'an, neither a Prophet nor an angel.'
Please keep forwarding this 'Hadith' to all ....because
Rasulullah (Sallallahu alaihe wasallam) said:
'Pass on knowledge from me even if it is only one verse'
...Include me too in your Supplication to Allah-almighty...with prays & regards...
'When a man dies and his relatives are busy in funeral, there stands an extremely handsome man by his head. When the dead body is shrouded, that man gets in between the shroud and the chest of the deceased.
When after the burial, the people return home, 2 angels, Munkar and Nakeer(names of two special Angels), come in the grave and try to separate this handsome man so that they may be able to interrogate the dead man in privacy about his faith. But the handsome man says, 'He is my companion, he is my friend. I will not leave him alone in any case. If you are appointed for interrogation, do your job. I cannot leave him until I get him admitted into Paradise '.
Thereafter he turns to his dead companion and says, 'I am the Qur'an, which you used to read, sometimes in a loud voice and sometimes in a low voice. Do not worry. After the interrogation of Munkar and Naker, you will have no grief.'
When the interrogation is over, the handsome man arranges for him from Al-Mala'ul A'laa (the angels in Heaven) silk bedding filled with musk.
Rasulullah (Sallallahu alaihe wasallam) said:
'On the Day of Judgement, before Allah, no other Intercessor will have a greater status than the Qur'an, neither a Prophet nor an angel.'
Please keep forwarding this 'Hadith' to all ....because
Rasulullah (Sallallahu alaihe wasallam) said:
'Pass on knowledge from me even if it is only one verse'
...Include me too in your Supplication to Allah-almighty...with prays & regards...
Friday, September 12, 2008
Wednesday, September 10, 2008
Bismillahir Rahman Nir Rahim!
The Holy Prophet (Peace be upon him & his progeny) Said:
1) Four things that make your body sick:
a) Excessive talking
b) Excessive sleeping
c) Excessive eating and
d) Excessive meeting other people
2) Four things that destroys the body:
a) Worrying
b) Sorrow (Sadness/Grief)
c) Hunger
d) Sleeping late in the night
3) Four things that dry the face & take away its happiness:
a) Lying
b) Being disrespectful / impudent (insisting on something wrong knowingly)
c) Arguing without adequate knowledge & Information.
d) Excessive immorality (doing something wrong without fear).
4) Four things that increases the wetness of face & its happiness:
a) Piety
b) Loyalty
c) Generosity (being kind)
d) To be helpful to others without he/she asking for that.
5) Four things that stop the Rizq (Sustenance) :
a) Sleeping in the morning (from Fajr to sunrise)
b) Not Performing Namaz or Ir-regular in Prayers
c) Laziness / Idleness
d) Treachery / Dishonesty
6) Four things that bring / increase the Rizq:
a) Staying up in the night for prayers.
b) Excessive Repentance
c) Regular Charity
d) Zikr (Remembrance of Allah / God).
The Holy Prophet (Peace be upon him & his progeny), Also said to communicate to
others even if you listen One Verse (Ayah) & this one verse will stand on the
Day of Judgment for intercession.
The Holy Prophet (SAW) said, Stop doing everything during the Azaan, even
reading the Quran, the person who talks during the Azaan will not be able to
say the Kalima A Shah ad a on his/her death bed.... Please pass this message to
Muslims... READ THIS DUAA FOR BETTER LIFE
Allahumma- inni- ala- Zikr-ika -wa Shuk-rika wa husni-ib ad -atika
A very powerful Dua'a has been sent to you. What do you think you should do
with it? Imagine if 1000 people read it just because of you. Jazakallah.
BECAUSE ONLY you will seek goodnesss but do not avoid this because that leads
to bitter life.
...Include me & my family too in all your Supplications to Allah-almighty...
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